2023
Schwarzová B, Stüdemann T, Sönmez M, Rössinger J, Pan B, Eschenhagen T, Stenzig J, Wiegert JS, Christ T, Weinberger F. Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES. Pflugers Arch. Dec;475(12):1463-1477. doi: 10.1007/s00424-023-02869-x.
Danyukova T, Alimy AR, Velho RV, Yorgan TA, Di Lorenzo G, von Kroge S, Tidow H, Wiegert JS, Hermans-Borgmeyer I, Schinke T, Rolvien T, Pohl S. Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage. Bone. 2023 Oct 3:116927. doi: 10.1016/j.bone.2023.116927.
Nicolas C, Ju A, Wu Y, Eldirdiri H, Delcasso S, Couderc Y, Fornari C, Mitra A, Supiot L, Vérité A, Masson M, Rodriguez-Rozada S, Jacky D, Wiegert JS, Beyeler A. Linking emotional valence and anxiety in a mouse insula-amygdala circuit. Nat Commun. 2023 Aug 21;14(1):5073. doi: 10.1038/s41467-023-40517-1.
Kagiampaki Z, Rohner V, Kiss C, Curreli S, Dieter A, Wilhelm M, Harada M, Duss SN, Dernic J, Bhat MA, Zhou X, Ravotto L, Ziebarth T, Wasielewski LM, Sönmez L, Benke D, Weber B, Bohacek J, Reiner A, Wiegert JS, Fellin T, Patriarchi T. Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nat Methods. 2023 Jul 20. doi: 10.1038/s41592-023-01959-z.
Wietek J, Nozownik A, Pulin M, Saraf-Sinik I, Matosevich N, Malan D, Brown BJ, Dine J, Levy R, Litvin A, Regev N, Subramaniam S, Bitton E, Benjamin A, Copits BA, Sasse P, Rost BR, Schmitz D, Soba P, Nir Y, Wiegert JS, Yizhar O. A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits. bioRxiv. 2023 Jul 2:2023.07.01.547328. doi: 10.1101/2023.07.01.547328.
Wiegert JS, Spehr M, Hanganu-Opatz IL. Systems neuroscience: A box full of tools to illuminate the black box of the brain. PLoS Biol. 2023 Jul 27;21(7): e3002221. doi: 10.1371/journal.pbio.3002221.
Quintana D, Bounds HA, Brown J, Wang M, Bhatla N, Wiegert JS, Adesnik H. Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations. bioRxiv. 2023 May 12:2023.05.11.540397. doi: 10.1101/2023.05.11.540397.
Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 Apr 6;14(1):1939. doi: 10.1038/s41467-023-37622-6.
Formozov A, Dieter A, Wiegert JS. A flexible and versatile system for multi-color fiber photometry and optogenetic manipulation. Cell Rep Methods. 2023 Mar 7;3(3):100418. doi: 10.1016/j.crmeth.2023.100418.
2022
Rodriguez-Rozada, S., Wietek, J., Tenedini, F. M., Sauter, K., Hegemann, P., Soba, P., & Wiegert, J.S. (2022). Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing. Commun Biol, 5, Article number: 687 (2022). (PubMed, PDF)
Wagdi, A., Malan, D., Sathyanarayanan, U., Beauchamp, J. S., Vogt, M., Zipf, D., Beiert, T., Mansuroglu, B., Dusend, V., Meininghaus, M., Schneider, L., Kalthof, B., Wiegert, J. S., Konig, G. M., Kostenis, E., Patejdl, R., Sasse, P., Bruegmann, T. (2022) Selective optogenetic control of Gq signaling using human Neuropsin. Nat Commun 13, 1765. (PubMed, PDF)
Formozov, A., Chini, M., Dieter, A., Yang, W., Pöpplau, J.A., Hanganu-Opatz, I.L., Wiegert, J.S., 2022. Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice. Scientific Data 9. (PubMed, PDF)
Formozov, A., Dieter, A., & Wiegert, J. S. (2022). A flexible and versatile system for multicolor fiber photometry and optogenetic manipulation. bioRxiv, 2022.2003.2016.484590. doi:10.1101/2022.03.16.484590
Kubitschke, M., Mueller, M., Wallhorn, L., Pulin, M., Mittag, M., Pollok, S., Ziebarth, T., Bremshey, S., Gerdey, J., Claussen, K.C., Renken, K., Gross, J., Meyer, N., Wiegert, J.S., Reiner, A., Fuhrmann, M., Masseck, O.A. (2022) sDarken: Next generation genetically encoded fluorescent sensors for serotonin. bioRxiv, 2022.2003.2010.483799. doi:10.1101/2022.03.10.483799
Anisimova M., van Bommel B., Wiegert J.S., Mikhaylova M., Oertner T.G., Gee C.E. (2022) Spike-timing-dependent plasticity rewards synchrony rather than causality. Cerebral Cortex. (PubMed, PDF)
Wissing, C., Maheu, M., Wiegert, J. S., and Dieter, A. (2022). Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies. bioRxiv, 2022.2001.2022.477348. doi:10.1101/2022.01.22.477348
Pulin, M., Stockhausen, K.E., Masseck, O.A., Kubitschke, M., Busse, B., Wiegert, J.S., and Oertner, T.G. (2022). Improved two-photon imaging of GPCR-based optogenetic neurotransmitter sensors using orthogonally polarized excitation. Biomed Opt Express 13(2): 777-790 (PubMed, PDF).
Imambocus, B.N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F.M., Hu, C., Sauter, K., Varela, E.M., Herédia, F., Casimiro, A.P., Schlegel, P., Yang, C.H., Miguel-Aliaga, I., Wiegert, J.S., Pankratz, M.J., Gontijo, A.M., Cardona, A., Soba, P. (2022). Discrete escape responses are generated by neuropeptide-mediated circuit logic. Current Biology 32 (1). (PubMed)
2021
Stuedemann, T., Roessinger, J., Manthey, C., Geertz, B., Srikantharajah, R., von Bibra, C.C., Shibamiya, A., Koehne, M., Wiehler, A., Wiegert, J.S., Eschenhagen, T., Weinberger, F. (2021). Contractile force of transplanted cardiomyocytes contributes to heart function after injury. bioRxiv: https://doi.org/10.1101/2021.11.23.469715
Nicolas, C., Ju, A., Wu, Y., Delcasso, S., Eldirdiri, H., Supiot, L., Fornari, C., Jacky, D., Vérité, A., Masson, M., Rodriguez-Rozada, S., Wiegert, J.S., Beyeler, A. Linking valence and anxiety in a mouse insula-amygdala circuit. Preprint: https://doi.org/10.21203/rs.3.rs-964107/v1
*Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is a tool for bidirectional dual-color optogenetic control of neurons. Nat Commun 12:4527. (PubMed, PDF)
* equal contributions
*Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 19;109(10):1621-1635.e8. (PubMed, PDF)
* equal contribution
*Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol 19(4): e3001146. (PubMed, PDF),
* equal contribution
2020
Westermann, L. M., L. Fleischhauer, J. Vogel, Z. Jenei-Lanzl, N. Floriano Ludwig, L. Schau, F. Morellini, A. Baranowsky, T. A. Yorgan, G. Di Lorenzo, M. Schweizer, B. de Souza Pinheiro, N. R. Guarany, F. Sperb-Ludwig, F. Visioli, T. Oliveira Silva, J. Soul, G. Hendrickx, J. S. Wiegert, I. V. D. Schwartz, H. Clausen-Schaumann, F. Zaucke, T. Schinke, S. Pohl and T. Danyukova (2020). "Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma." Dis Model Mech (Pubmed)
Duerst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., and Oertner, T.G. (2020). The vesicular release probability sets the strength of individual Schaffer collateral synapses. bioRxiv, 2020.2008.2002.232850 (PDF).
Perez-Alvarez, A., Fearey, B.C., O'Toole, R.J., Yang, W., Arganda-Carreras, I., Lamothe-Molina, P.J., Moeyaert, B., Mohr, M.A., Panzera, L.C., Schulze, C., Schreiter, E.R., Wiegert, J.S., Gee, C.E., Hoppa, M.B., Oertner, T.G. (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun 11, 2464 (Pubmed, PDF)
2019
Oppermann, J., P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Béjà, P. Hegemann and J. Wietek (2019). "MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing channelrhodopsins." Nat Commun 10(1): 3315. (Pubmed, PDF)
Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. (2019). Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci (Pubmed, PDF)
Yizhar, O. and Wiegert, J.S., (2019). Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. Trends Pharmacol Sci 40(6): 362-364. (Pubmed, PDF)
Durst, C.D., Wiegert, J.S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., Geeves, M.A., Torok, K., and Oertner, T.G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Protoc 14(5): 1401-1424. (PubMed, PDF)
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner , T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7 (PubMed, PDF)
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun (PubMed, PDF)
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Fast glutamate sensors resolve short-term synaptic plasticity, Proc Natl Acad Sci USA (PubMed, PDF)
2017
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7: 14957 (PubMed, PDF)
Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95 (3), 504-529 (PubMed, PDF)
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Comm 8: 14563 (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
2016
Wiegert, J. S. and Oertner T. G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19(4): 527-528 (PubMed, PDF)
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5: 14807 (PubMed, PDF)
Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327 (PubMed, PDF)
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Oertner, T.G., Vetter, T. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97 (PubMed, PDF)
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412,
*equal contribution (PubMed, PDF, Supplement)
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024 (PubMed, PDF, Supplement)
2013
Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519 (PubMed, PDF, Supplement)
2007 - 2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478 (PubMed, PDF, Supplement)
Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus. Nucleus 2(2), 1-7 (PubMed, PDF)
Wiegert, J. S. and Oertner , T. G. (2011). Shapeshifting for memory. e-Neuroforum 2(1), 6-12 (PDF)
Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305 (PubMed, PDF)
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980 (PubMed, PDF, Supplement)
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. (first 6 authors equally contributing) (PubMed, PDF, Supplement)
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124 (PubMed, PDF, Supplement)
Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633 (PubMed, PDF)
Schwarzová B, Stüdemann T, Sönmez M, Rössinger J, Pan B, Eschenhagen T, Stenzig J, Wiegert JS, Christ T, Weinberger F. Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES. Pflugers Arch. Dec;475(12):1463-1477. doi: 10.1007/s00424-023-02869-x.
Danyukova T, Alimy AR, Velho RV, Yorgan TA, Di Lorenzo G, von Kroge S, Tidow H, Wiegert JS, Hermans-Borgmeyer I, Schinke T, Rolvien T, Pohl S. Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage. Bone. 2023 Oct 3:116927. doi: 10.1016/j.bone.2023.116927.
Nicolas C, Ju A, Wu Y, Eldirdiri H, Delcasso S, Couderc Y, Fornari C, Mitra A, Supiot L, Vérité A, Masson M, Rodriguez-Rozada S, Jacky D, Wiegert JS, Beyeler A. Linking emotional valence and anxiety in a mouse insula-amygdala circuit. Nat Commun. 2023 Aug 21;14(1):5073. doi: 10.1038/s41467-023-40517-1.
Kagiampaki Z, Rohner V, Kiss C, Curreli S, Dieter A, Wilhelm M, Harada M, Duss SN, Dernic J, Bhat MA, Zhou X, Ravotto L, Ziebarth T, Wasielewski LM, Sönmez L, Benke D, Weber B, Bohacek J, Reiner A, Wiegert JS, Fellin T, Patriarchi T. Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nat Methods. 2023 Jul 20. doi: 10.1038/s41592-023-01959-z.
Wietek J, Nozownik A, Pulin M, Saraf-Sinik I, Matosevich N, Malan D, Brown BJ, Dine J, Levy R, Litvin A, Regev N, Subramaniam S, Bitton E, Benjamin A, Copits BA, Sasse P, Rost BR, Schmitz D, Soba P, Nir Y, Wiegert JS, Yizhar O. A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits. bioRxiv. 2023 Jul 2:2023.07.01.547328. doi: 10.1101/2023.07.01.547328.
Wiegert JS, Spehr M, Hanganu-Opatz IL. Systems neuroscience: A box full of tools to illuminate the black box of the brain. PLoS Biol. 2023 Jul 27;21(7): e3002221. doi: 10.1371/journal.pbio.3002221.
Quintana D, Bounds HA, Brown J, Wang M, Bhatla N, Wiegert JS, Adesnik H. Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations. bioRxiv. 2023 May 12:2023.05.11.540397. doi: 10.1101/2023.05.11.540397.
Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 Apr 6;14(1):1939. doi: 10.1038/s41467-023-37622-6.
Formozov A, Dieter A, Wiegert JS. A flexible and versatile system for multi-color fiber photometry and optogenetic manipulation. Cell Rep Methods. 2023 Mar 7;3(3):100418. doi: 10.1016/j.crmeth.2023.100418.
2022
Rodriguez-Rozada, S., Wietek, J., Tenedini, F. M., Sauter, K., Hegemann, P., Soba, P., & Wiegert, J.S. (2022). Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing. Commun Biol, 5, Article number: 687 (2022). (PubMed, PDF)
Wagdi, A., Malan, D., Sathyanarayanan, U., Beauchamp, J. S., Vogt, M., Zipf, D., Beiert, T., Mansuroglu, B., Dusend, V., Meininghaus, M., Schneider, L., Kalthof, B., Wiegert, J. S., Konig, G. M., Kostenis, E., Patejdl, R., Sasse, P., Bruegmann, T. (2022) Selective optogenetic control of Gq signaling using human Neuropsin. Nat Commun 13, 1765. (PubMed, PDF)
Formozov, A., Chini, M., Dieter, A., Yang, W., Pöpplau, J.A., Hanganu-Opatz, I.L., Wiegert, J.S., 2022. Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice. Scientific Data 9. (PubMed, PDF)
Formozov, A., Dieter, A., & Wiegert, J. S. (2022). A flexible and versatile system for multicolor fiber photometry and optogenetic manipulation. bioRxiv, 2022.2003.2016.484590. doi:10.1101/2022.03.16.484590
Kubitschke, M., Mueller, M., Wallhorn, L., Pulin, M., Mittag, M., Pollok, S., Ziebarth, T., Bremshey, S., Gerdey, J., Claussen, K.C., Renken, K., Gross, J., Meyer, N., Wiegert, J.S., Reiner, A., Fuhrmann, M., Masseck, O.A. (2022) sDarken: Next generation genetically encoded fluorescent sensors for serotonin. bioRxiv, 2022.2003.2010.483799. doi:10.1101/2022.03.10.483799
Anisimova M., van Bommel B., Wiegert J.S., Mikhaylova M., Oertner T.G., Gee C.E. (2022) Spike-timing-dependent plasticity rewards synchrony rather than causality. Cerebral Cortex. (PubMed, PDF)
Wissing, C., Maheu, M., Wiegert, J. S., and Dieter, A. (2022). Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies. bioRxiv, 2022.2001.2022.477348. doi:10.1101/2022.01.22.477348
Pulin, M., Stockhausen, K.E., Masseck, O.A., Kubitschke, M., Busse, B., Wiegert, J.S., and Oertner, T.G. (2022). Improved two-photon imaging of GPCR-based optogenetic neurotransmitter sensors using orthogonally polarized excitation. Biomed Opt Express 13(2): 777-790 (PubMed, PDF).
Imambocus, B.N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F.M., Hu, C., Sauter, K., Varela, E.M., Herédia, F., Casimiro, A.P., Schlegel, P., Yang, C.H., Miguel-Aliaga, I., Wiegert, J.S., Pankratz, M.J., Gontijo, A.M., Cardona, A., Soba, P. (2022). Discrete escape responses are generated by neuropeptide-mediated circuit logic. Current Biology 32 (1). (PubMed)
2021
Stuedemann, T., Roessinger, J., Manthey, C., Geertz, B., Srikantharajah, R., von Bibra, C.C., Shibamiya, A., Koehne, M., Wiehler, A., Wiegert, J.S., Eschenhagen, T., Weinberger, F. (2021). Contractile force of transplanted cardiomyocytes contributes to heart function after injury. bioRxiv: https://doi.org/10.1101/2021.11.23.469715
Nicolas, C., Ju, A., Wu, Y., Delcasso, S., Eldirdiri, H., Supiot, L., Fornari, C., Jacky, D., Vérité, A., Masson, M., Rodriguez-Rozada, S., Wiegert, J.S., Beyeler, A. Linking valence and anxiety in a mouse insula-amygdala circuit. Preprint: https://doi.org/10.21203/rs.3.rs-964107/v1
*Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is a tool for bidirectional dual-color optogenetic control of neurons. Nat Commun 12:4527. (PubMed, PDF)
* equal contributions
*Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 19;109(10):1621-1635.e8. (PubMed, PDF)
* equal contribution
*Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol 19(4): e3001146. (PubMed, PDF),
* equal contribution
2020
Westermann, L. M., L. Fleischhauer, J. Vogel, Z. Jenei-Lanzl, N. Floriano Ludwig, L. Schau, F. Morellini, A. Baranowsky, T. A. Yorgan, G. Di Lorenzo, M. Schweizer, B. de Souza Pinheiro, N. R. Guarany, F. Sperb-Ludwig, F. Visioli, T. Oliveira Silva, J. Soul, G. Hendrickx, J. S. Wiegert, I. V. D. Schwartz, H. Clausen-Schaumann, F. Zaucke, T. Schinke, S. Pohl and T. Danyukova (2020). "Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma." Dis Model Mech (Pubmed)
Duerst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., and Oertner, T.G. (2020). The vesicular release probability sets the strength of individual Schaffer collateral synapses. bioRxiv, 2020.2008.2002.232850 (PDF).
Perez-Alvarez, A., Fearey, B.C., O'Toole, R.J., Yang, W., Arganda-Carreras, I., Lamothe-Molina, P.J., Moeyaert, B., Mohr, M.A., Panzera, L.C., Schulze, C., Schreiter, E.R., Wiegert, J.S., Gee, C.E., Hoppa, M.B., Oertner, T.G. (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun 11, 2464 (Pubmed, PDF)
2019
Oppermann, J., P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Béjà, P. Hegemann and J. Wietek (2019). "MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing channelrhodopsins." Nat Commun 10(1): 3315. (Pubmed, PDF)
Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. (2019). Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci (Pubmed, PDF)
Yizhar, O. and Wiegert, J.S., (2019). Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. Trends Pharmacol Sci 40(6): 362-364. (Pubmed, PDF)
Durst, C.D., Wiegert, J.S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., Geeves, M.A., Torok, K., and Oertner, T.G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Protoc 14(5): 1401-1424. (PubMed, PDF)
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner , T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7 (PubMed, PDF)
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun (PubMed, PDF)
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Fast glutamate sensors resolve short-term synaptic plasticity, Proc Natl Acad Sci USA (PubMed, PDF)
2017
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7: 14957 (PubMed, PDF)
Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95 (3), 504-529 (PubMed, PDF)
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Comm 8: 14563 (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
2016
Wiegert, J. S. and Oertner T. G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19(4): 527-528 (PubMed, PDF)
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5: 14807 (PubMed, PDF)
Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327 (PubMed, PDF)
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Oertner, T.G., Vetter, T. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97 (PubMed, PDF)
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412,
*equal contribution (PubMed, PDF, Supplement)
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024 (PubMed, PDF, Supplement)
2013
Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519 (PubMed, PDF, Supplement)
2007 - 2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478 (PubMed, PDF, Supplement)
Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus. Nucleus 2(2), 1-7 (PubMed, PDF)
Wiegert, J. S. and Oertner , T. G. (2011). Shapeshifting for memory. e-Neuroforum 2(1), 6-12 (PDF)
Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305 (PubMed, PDF)
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980 (PubMed, PDF, Supplement)
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. (first 6 authors equally contributing) (PubMed, PDF, Supplement)
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124 (PubMed, PDF, Supplement)
Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633 (PubMed, PDF)
