2021
*Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is a tool for bidirectional dual-color optogenetic control of neurons. Nat Commun 12:4527. (PubMed, PDF)
* equal contributions
*Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 19;109(10):1621-1635.e8. (PubMed, PDF)
* equal contribution
*Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol 19(4): e3001146. (PubMed, PDF),
* equal contribution
2020
Westermann, L. M., L. Fleischhauer, J. Vogel, Z. Jenei-Lanzl, N. Floriano Ludwig, L. Schau, F. Morellini, A. Baranowsky, T. A. Yorgan, G. Di Lorenzo, M. Schweizer, B. de Souza Pinheiro, N. R. Guarany, F. Sperb-Ludwig, F. Visioli, T. Oliveira Silva, J. Soul, G. Hendrickx, J. S. Wiegert, I. V. D. Schwartz, H. Clausen-Schaumann, F. Zaucke, T. Schinke, S. Pohl and T. Danyukova (2020). "Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma." Dis Model Mech (Pubmed)
Duerst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., and Oertner, T.G. (2020). The vesicular release probability sets the strength of individual Schaffer collateral synapses. bioRxiv, 2020.2008.2002.232850 (PDF).
Perez-Alvarez, A., Fearey, B.C., O'Toole, R.J., Yang, W., Arganda-Carreras, I., Lamothe-Molina, P.J., Moeyaert, B., Mohr, M.A., Panzera, L.C., Schulze, C., Schreiter, E.R., Wiegert, J.S., Gee, C.E., Hoppa, M.B., Oertner, T.G. (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun 11, 2464 (Pubmed, PDF)
2019
Oppermann, J., P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Béjà, P. Hegemann and J. Wietek (2019). "MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing channelrhodopsins." Nat Commun 10(1): 3315. (Pubmed, PDF)
Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. (2019). Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci (Pubmed, PDF)
Yizhar, O. and Wiegert, J.S., (2019). Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. Trends Pharmacol Sci 40(6): 362-364. (Pubmed, PDF)
Durst, C.D., Wiegert, J.S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., Geeves, M.A., Torok, K., and Oertner, T.G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Protoc 14(5): 1401-1424. (PubMed, PDF)
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner , T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7 (PubMed, PDF)
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun (PubMed, PDF)
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Fast glutamate sensors resolve short-term synaptic plasticity, Proc Natl Acad Sci USA (PubMed, PDF)
2017
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7: 14957 (PubMed, PDF)
Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95 (3), 504-529 (PubMed, PDF)
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Comm 8: 14563 (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
2016
Wiegert, J. S. and Oertner T. G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19(4): 527-528 (PubMed, PDF)
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5: 14807 (PubMed, PDF)
Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327 (PubMed, PDF)
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Oertner, T.G., Vetter, T. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97 (PubMed, PDF)
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412,
*equal contribution (PubMed, PDF, Supplement)
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024 (PubMed, PDF, Supplement)
2013
Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519 (PubMed, PDF, Supplement)
2007 - 2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478 (PubMed, PDF, Supplement)
Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus. Nucleus 2(2), 1-7 (PubMed, PDF)
Wiegert, J. S. and Oertner , T. G. (2011). Shapeshifting for memory. e-Neuroforum 2(1), 6-12 (PDF)
Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305 (PubMed, PDF)
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980 (PubMed, PDF, Supplement)
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. (first 6 authors equally contributing) (PubMed, PDF, Supplement)
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124 (PubMed, PDF, Supplement)
Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633 (PubMed, PDF)
*Vierock, J., *Rodriguez-Rozada, S., Dieter, A., Pieper, F., Sims, R., Tenedini, F., Bergs, A.C.F., Bendifallah, I., Zhou, F., Zeitzschel, N., Ahlbeck, J., Augustin S., Sauter, K., Papagiakoumou, E., Gottschalk, A., Soba, P., Emiliani, V., Engel, A.K., Hegemann, P., Wiegert, J.S. (2021). BiPOLES is a tool for bidirectional dual-color optogenetic control of neurons. Nat Commun 12:4527. (PubMed, PDF)
* equal contributions
*Mahn, M., *Saraf-Sinik, I., *Patil, P., *Pulin, M., Bitton, E., Karalis, N., Bruentgens, F., Palgi, S., Gat, A., Dine, J., Wietek, J., Davidi, I., Levy, R., Litvin, A., Zhou, F., Sauter, K., Soba, P., Schmitz, D., Lüthi, A., Rost, B.R., Wiegert, J.S., Yizhar, O. (2021). Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin. Neuron 19;109(10):1621-1635.e8. (PubMed, PDF)
* equal contribution
*Yang, W., *Chini, M., Poepplau, J.A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I.L., Wiegert, J.S. (2021). Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLOS Biol 19(4): e3001146. (PubMed, PDF),
* equal contribution
2020
Westermann, L. M., L. Fleischhauer, J. Vogel, Z. Jenei-Lanzl, N. Floriano Ludwig, L. Schau, F. Morellini, A. Baranowsky, T. A. Yorgan, G. Di Lorenzo, M. Schweizer, B. de Souza Pinheiro, N. R. Guarany, F. Sperb-Ludwig, F. Visioli, T. Oliveira Silva, J. Soul, G. Hendrickx, J. S. Wiegert, I. V. D. Schwartz, H. Clausen-Schaumann, F. Zaucke, T. Schinke, S. Pohl and T. Danyukova (2020). "Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma." Dis Model Mech (Pubmed)
Duerst, C., Wiegert, J.S., Schulze, C., Helassa, N., Török, K., and Oertner, T.G. (2020). The vesicular release probability sets the strength of individual Schaffer collateral synapses. bioRxiv, 2020.2008.2002.232850 (PDF).
Perez-Alvarez, A., Fearey, B.C., O'Toole, R.J., Yang, W., Arganda-Carreras, I., Lamothe-Molina, P.J., Moeyaert, B., Mohr, M.A., Panzera, L.C., Schulze, C., Schreiter, E.R., Wiegert, J.S., Gee, C.E., Hoppa, M.B., Oertner, T.G. (2020). Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun 11, 2464 (Pubmed, PDF)
2019
Oppermann, J., P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Béjà, P. Hegemann and J. Wietek (2019). "MerMAIDs: A novel family of metagenomically discovered, marine, anion-conducting and intensely desensitizing channelrhodopsins." Nat Commun 10(1): 3315. (Pubmed, PDF)
Binder, S., Molle, M., Lippert, M., Bruder, R., Aksamaz, S., Ohl, F., Wiegert, J.S., and Marshall, L. (2019). Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. J Neurosci (Pubmed, PDF)
Yizhar, O. and Wiegert, J.S., (2019). Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics. Trends Pharmacol Sci 40(6): 362-364. (Pubmed, PDF)
Durst, C.D., Wiegert, J.S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., Geeves, M.A., Torok, K., and Oertner, T.G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. Nat Protoc 14(5): 1401-1424. (PubMed, PDF)
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner , T. G. (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7 (PubMed, PDF)
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun (PubMed, PDF)
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. (2018). Fast glutamate sensors resolve short-term synaptic plasticity, Proc Natl Acad Sci USA (PubMed, PDF)
2017
Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F., Grimm, C., Oertner, T.G., Soba, P., Hegemann, P., Wiegert, J.S. (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7: 14957 (PubMed, PDF)
Wiegert, J. S., Mahn, M., Prigge, M. Prinz, Y., Yizhar, O. (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95 (3), 504-529 (PubMed, PDF)
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Comm 8: 14563 (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc 2017 (2) (PubMed, PDF)
2016
Wiegert, J. S. and Oertner T. G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19(4): 527-528 (PubMed, PDF)
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5: 14807 (PubMed, PDF)
Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327 (PubMed, PDF)
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Oertner, T.G., Vetter, T. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97 (PubMed, PDF)
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412,
*equal contribution (PubMed, PDF, Supplement)
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024 (PubMed, PDF, Supplement)
2013
Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519 (PubMed, PDF, Supplement)
2007 - 2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478 (PubMed, PDF, Supplement)
Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus. Nucleus 2(2), 1-7 (PubMed, PDF)
Wiegert, J. S. and Oertner , T. G. (2011). Shapeshifting for memory. e-Neuroforum 2(1), 6-12 (PDF)
Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305 (PubMed, PDF)
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980 (PubMed, PDF, Supplement)
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. (first 6 authors equally contributing) (PubMed, PDF, Supplement)
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124 (PubMed, PDF, Supplement)
Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633 (PubMed, PDF)
